INTRODUCTION A community-based project was developed to support quit attempts and denormalise smoking in Aboriginal communities. This qualitative study evaluates the effectiveness of project strategies, messages and the partnership process, and explores impacts observed by Aboriginal community members, complementing findings from a quantitative evaluation. METHODS The study comprised five focus groups (40 participants) and 14 in-depth interviews (with 15 community members). Data were analysed thematically by manual and NVivo software methods. RESULTS Results demonstrate that the project attracted community attention, was well recalled and messages were considered convincing and persuasive. Participants reported being more likely to quit and to discuss smoking with family and friends, and noticed that many people were quitting. Participants observed an increase in asking people not to smoke in the home and fewer people smoking at events, but noted that many smokers struggled to stay quit. The partnership and participation of Aboriginal Health Workers were viewed as crucial. CONCLUSION The qualitative findings reinforce quantitative evaluation findings suggesting that the project contributed to denormalising smoking and motivating quit attempts. SO WHAT The evaluation provided insight into how the project changed attitudes and motivated community members to make quit attempts and provided ideas to meet the ongoing challenge. SUMMARY Qualitative evaluation of this community-based Aboriginal tobacco project provided insight and detail into processes of change in the community, lending weight to the importance of tailored messages, working to change social norms about smoking, and providing motivation to smokers to make quit attempts. This article is protected by copyright. All rights reserved.Chiral β-aminoalkylzinc halides were prepared starting from optically pure commercial β-amino-alcohols. These amino-alcohols were converted to the corresponding N-pyrrolyl-protected alkyl iodides which undergo a zinc insertion in the presence of LiCl (THF, 25 °C, 10-90 min). Subsequent Negishi cross-couplings or acylations with acid chlorides produced amino-derivatives with retention of chirality. Diastereoselective CBS-reductions of some prepared N-pyrrolyl-ketones provided 1,3-subsituted N-pyrrolyl-alcohols with high diastereoselectivity. Additionally, a deprotection procedure involving an ozonolysis allowed the conversion of the pyrrole-ring into a formamide without loss of optical purity. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.OBJECTIVE Septo-optic dysplasia (SOD) is a clinical syndrome characterized by varying combinations of optic nerve hypoplasia, pituitary gland hypoplasia and abnormal cavum septum pellucidum. It is suspected on prenatal imaging when there is non-visualization or hypoplasia of the septal leaflets. Long-term postnatal outcomes of fetuses with prenatally suspected SOD have been poorly documented. Our aims were to describe the natural history of deficient septal leaflets, to quantify the incidence of postnatally confirmed SOD, and to document the long-term visual, endocrine and neurodevelopmental outcomes of these infants. METHODS An observational retrospective study of all fetuses with prenatal imaging showing isolated septal agenesis, assessed at a single tertiary centre over a 10-year period. Pregnancy, delivery, pre- and postnatal imaging and neonatal outcomes were reviewed for clinical confirmation of SOD. Long-term ophthalmologic, endocrine, developmental and genetic evaluations were assessed. RESULTS Of 214 visual or endocrine abnormalities to confirm SOD had normal development. CONCLUSION Only a quarter of individuals with isolated septal agenesis suggestive of SOD will have postnatal confirmation of the diagnosis. Clinical manifestations of SOD are variable, but neurodevelopmental delay may be more prevalent than formerly thought. This article is protected by copyright. All rights reserved. This article is protected by copyright. https://www.selleckchem.com/products/AZD0530.html All rights reserved.In livestock, improving maternal reactivity towards the litter is an important issue in breeding strategies to promote production and animal welfare. As of yet, no studies have investigated the within-breed genetic variation of maternal reactivity in sheep. The objective of this study was to estimate the genetic parameters of maternal reactivity traits. A total of 1,095 primiparous and 1,441 multiparous Romane ewes were phenotyped 24&nbsp;hr postlambing using a behavioural test (arena test, AT) over a 10-year experimental period. The test consisted of three successive phases evaluating the ewe's attraction to her litter, reactivity to separation from her litter, and reactivity to a conflict between attraction to her litter and avoidance of a motionless human. The ewes were reared exclusively on rangelands (South of France) and lambed outdoors in the spring. High-pitched bleating and low-pitched bleating in the AT were mostly highly heritable (0.39-0.46). Heritabilities were moderate for proximity to the litter in the presence of a human (0.27) and low for locomotion and vigilance in the AT (0.09-0.15). The measurements of a given behaviour in the three phases of the AT were highly genetically correlated. Few genetic correlations were found between the different behavioural traits in the AT, the highest correlations being between high-pitched bleating and low-pitched bleating (-0.43 to -0.77). In conclusion, our findings demonstrate moderate-to-high heritability for maternal reactivity traits. These traits could be included in genetic selection schemes to enhance maternal attachment provided there is no unfavourable link with other production traits. © 2020 Blackwell Verlag GmbH.While perfluorinated aryl, aryloxy and alkoxy aluminum species are well-established as weakly coordinating anions (WCAs), corresponding perfluoroalkyl aluminum derivatives are virtually unknown.&nbsp; Reaction of Si(C 2 F 5 ) 3 CH 3 &nbsp;with Li[AlH 4 ] afforded the tetrakis(pentafluoroethyl)aluminate, [ Al(C 2 F 5 ) 4 ] - . Several salts of the&nbsp; [ Al(C 2 F 5 ) 4 ] - &nbsp;ion were synthesized and characterized by NMR spectroscopic methods, mass spectrometry, X-ray diffraction studies and elemental analysis. © 2020 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.